Monday 4 May 2020

How does Corona 19 affect the brain?

      How does Corona 19 affect the brain?


The new evidence suggests that coronavirus can harm other organs besides the lungs. Some neurologists have explained how the virus affects the brain.

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How does Corona 19 affect the brain? Finding an answer to this question is one of the new concerns of doctors and scientists. Since there is already evidence that corona 19 affects the kidneys and heart, there is a story that the virus is a multiline disease.

This is a big difference compared to other viral pathologies such as influenza. These diseases only cause respiratory symptoms and, at best, fever.


However, studies of corona viruses point to ACE2 cell receptors that enter other cells of the body. The ACE2 receptors described in this article are present in many parts of our body, and Corona19 uses this protein to affect the brain.

It is worth emphasizing that the well-known and normal symptoms such as fever, cough, fatigue and shortness of breath remain. However, more and more people have secondary signs that help to detect infections early and save time. We have already dealt with visual problems and loss of smell.


But we also need to add new research on neurological factors.

ACE2 receptor
The corona virus has a crown-shaped outer form, which is why its name comes from. And this crown is made up of spicules with the proteins needed to access human cells. The human receptor is the ACE2 protein.


This receptor is present in the human body to interact in a system called lenin- angiotensin. This hormone and internal substance system is actively involved in blood pressure control. Therefore, this includes even height.

COVID-19 affects the brain because some neurons have ACE2 receptors. Although no complete confirmation of neuropathy or affinity for neurons by SARS-Co V-2 has been made, there are several grounds for doubt.


The relevance of the ACE2 receptor is very important in understanding corona virus mortality. Other studies show that people with hypertensive disorders belong to a group with a high mortality rate, which can be explained by the effects of the Lenin-Angiotensin system.


Symptoms when Corona 19 affects the brain
Loss of smell was an early symptom of corona virus, as pointed out by the World Medical Association. It is said that this symptom is due to the neurological orientation of SARS-Co V-2. The name given here is loss of smell, and neurologists agree that these symptoms may be caused by problems with neurons belonging to the olfactory system.


Cases of corona virus infections with myositis (muscle inflammation), Guillain-Barre syndrome and meningitis have also been described. All of these may also be related to the central and peripheral nervous system.

An important risk for corona 19's effect on the brain is related to the structure of the brain's blood vessels. In addition to the possible orientation of SARS-Co V-2 in neurons, the inner layer of the brain arteries may also be damaged.


We know this micro-endothelial damage is a microangiopathy. In the worst case scenario, this can lead to intracranial hemorrhage and stroke.

2 pathways for brain damage


Corona virus is a systemic disease and can affect organs other than the lungs.

There are two possible routes Corona 19 takes to influence the brain. One of them is more direct and is based on the viral neuronal hypothesis. The other route is indirect and is due to several traumatized organs when the patient is severely traumatized in the intensive care unit.

However, the direct route has not been fully proven. SARS-Co V-2 enters neurons through the ACE2 receptor in the same way it enters the lungs and kidneys.


On the other hand, an indirect pathway is one that affects the evolution of corona virus in the body. First we have respiratory problems, then pneumonia, insufficiency of several organs, reduced blood flow to the brain, and, consequently, death of neurons that do not receive enough oxygen.

Conclusion: Will Corona 19 affect the brain?
Overall, we know that corona 19 directly or indirectly affects the brain. And on the one hand, scientific research will continue to be informed and new aspects of this pandemic will be revealed.


This information is especially important for the intensive care unit staff who can tailor the treatment to the outcome. In addition, this valuable information will add hope to the uncertainty of corona virus outbreaks worldwide and increase patient survival.


Mani

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